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The Zanos lab welcomes our new ONISILOS Marie Sklodowska Curie fellow, Dr. Andrea Georgiou.
Her proposed case-control study (participants that achieved abstinence for at least 6 months after smoking cessation versus participants that did not achieve abstinence) aims to identify novel genetically-supported drug targets for smoking cessation and to correlate/associate changes in those druggable protein targets with: (a) motivation to quit smoking and (b) vulnerability to relapse following abstinence. For […]
OUR NEW PRE-PRINT: (2R,6R)-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent mice
In the realm of opioid addiction crisis faced by many parts of the world, a significant challenge is the high relapse rates during periods of abstinence, often triggered by stress and negative emotional states. Our findings advance our understanding on opioid addiction neurobiology and treatment options by exploring the therapeutic potential of (2R,6R)-hydroxynorketamine (HNK) in […]
NEW BIOINFORMATICS MANUSCRIPT: From Viral Infections to Alzheimer’s Disease: Unveiling the Mechanistic Links Through Systems Bioinformatics
Viruses Might Influence the Development of Alzheimer’s Disease!! Scientists have long been curious about the connection between viral infections and the onset of Alzheimer’s Disease (AD), a debilitating condition characterized by memory loss and cognitive decline. Here, we used a systems bioinformatics approach to explore the potential roles of various viruses, including Herpes Simplex Virus […]
Dr. Zanos presents our latest findings on novel mechanisms underlying ketamine’s antidepressant action
The Director of the Translational Neuropharmacology Lab, Dr. Zanos, presented our latest data concerning the potential role of NMDA receptor activation underlying ketamine’s antidepressant mechanism of action. This invited talk was a part of the Hellenic Society for Neuroscience (HSfN) conference. Dr. Zanos’s talk centered on revealing the crucial role of NMDA receptor activation in facilitating […]
NEW PUBLICATION: Unraveling the transcriptomic signatures of Parkinson’s Disease and Major Depression using single-cell and bulk data
Curious to know what Parkinson’s disease and Major depression have in common? So are we! Explore our latest publication, where we analyze single-cell and bulk data to unravel their transcriptomic signatures. https://www.frontiersin.org/articles/10.3389/fnagi.2023.1273855/abstract Transnational Neuropharmacology Lab
Dr. Zanos Delivers Invited Lecture to the General Public: “Understanding the Effects of Drugs of Abuse on the Brain and Discovering Innovative Pharmacotherapies”
We are excited to announce that Dr. Zanos was invited to deliver a special lecture to the general public, shedding light on the profound impact of drugs of abuse on the brain and presenting innovative pharmacotherapies. In this engaging and informative presentation, Dr. Zanos shared his expertise on the subject, providing valuable insights into the […]
Dr. Zanos Presents Groundbreaking Research at the Mediterranean Neuroscience Society Conference
Dr. Zanos recently presented our laboratory’s groundbreaking findings at the Mediterranean Neuroscience Society conference held in Tunis (https://www.medneuroscisociety.org/mns2023_info). His presentation focused on the novel discoveries surrounding the paradigm-shifting mechanisms responsible for the rapid-antidepressant efficacy of ketamine and other potential compounds currently in clinical phase development. This presentation highlights the significant contributions of our laboratory to […]
NEW PUBLICATION: NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine
Check out our new publication in the Journal of Neuroscience: https://www.jneurosci.org/content/43/6/1038 The anesthetic and antidepressant drug ketamine is well-characterized as an NMDA receptor (NMDAR) antagonist; though, the relevance and full impact of this pharmacology to its antidepressant actions is unclear. We found that NMDAR activation, which occurs downstream of their initial actions, is necessary for […]