Dr. Mary Haddad, BSc, MSc, Ph.D.
Postdoctoral, Marie Skłodowska-Curie Fellow
Dr. Haddad’s research interests revolve around exploring the complex interplay between molecular mechanisms, particularly focusing on the role of soluble epoxide hydrolase (sEH) and its inhibitors in conditions like depression, pain, inflammation, and neurodegenerative diseases. Her work delves into the connection between oxidative stress, depression, and the potential therapeutic implications of omega-3 polyunsaturated fatty acids in mitigating inflammation through the modulation of lipid mediators. Additionally, Dr. Haddad investigates the involvement of 20-HETE enzymes and receptors within the neurovascular unit, emphasizing their implications in cerebrovascular diseases, thus contributing significantly to our understanding of these complex physiological and pathological processes.
Dr. Haddad’s project in Dr. Zanos’s lab investigates the relationship between 20-HETE and EET metabolites in depression, exploring their link to inflammation and proposing novel therapeutic avenues. This involves characterizing CYP involvement in depressive symptoms, studying pharmacological interventions in rodents, and assessing the impact on neuronal function and pathology, aiming to translate these findings into potential clinical relevance for Major Depressive Disorder.
Selected Publications:
- Dannawi M, Riachi ME, Haddad AF, El Massry M, Haddad M, Moukarzel P et al. Influence of intermittent fasting on prediabetes-induced neuropathy: Insights on a novel mechanistic pathway. Metabol Open 2022; 14: 100175. https://doi.org/10.1016/j.metop.2022.100175.
- Haddad M, Eid S, Harb F, Massry MEL, Azar S, Sauleau EA et al. Activation of 20-HETE Synthase Triggers Oxidative Injury and Peripheral Nerve Damage in Type 2 Diabetic Mice. J Pain 2022; 23(8): 1371-1388. https://doi.org/10.1016/j.jpain.2022.02.011.
Contact info:
E-mail: mah92@mail.aub.edu