Dr. Andrea Georgiou, BSc, MSc, Ph.D.
Research Interests: Her research interests intersect genetics, epidemiology, drug repurposing and biostatistics, with a central focus on advancing our understanding of complex diseases, particularly within the realm of neuropsychiatric conditions, and the interplay of genetic and environmental determinants. Over the years, she has actively engaged in a diverse array of projects, spanning genetic epidemiology investigations involving mendelian randomization, polygenic risk scores, and genome- and protein-wide association analyses for complex diseases, including neurodegenerative and cardiovascular conditions. Her work also encompasses conducting observational studies that entail participant recruitment. She is deeply passionate about unraveling the genetic and environmental factors that contribute to complex health issues and leveraging this knowledge to shape public health interventions and inform medical practices.
For more information please visit:
Selected Publications:
- Georgiou A, Voskarides K, Zanos P, Chatzittofis A. Investigating the shared genetic basis and causal relationships between mucosa-associated lymphoid tissue inflammation and psychiatric disorders. Frontiers in Psychiatry, 2024, In Press. https://doi.org/10.3389/fpsyt.2024.1379922
- Georgiou A, Zagkos L, Markozannes G, Chalitsios CV, Asimakopoulos AG, Xu W, Wang L, Mesa-Eguiagaray I, Zhou X, Loizidou EM, Kretsavos N, Theodoratou E, Gill D, Burgess S, Evangelou E, Tsilidis KK, Tzoulaki I. Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies. J Am Heart Assoc. 2023 Oct 17;12(20):e029040. https://doi.org/10.1161/JAHA.122.029040.
- Georgiou A, Georgiopoulos G, Delialis D, Maneta E, Masci PG, Neophytou O, Tsiachris D, Evangelou E. The causal relationship between average alcohol consumption and risk of atrial fibrillation: a Mendelian randomization study, Circulation: Genomic and Precision Medicine, 2023 May 16:406–408. https://doi.org/10.1161/CIRCGEN.122.003766.
- Chalitsios CV, Georgiou A, Bouras E, Evangelou E, Gill D, Tsilidis KK, Tzoulaki I. Investigating modifiable pathways in psoriasis: A Mendelian randomization study. J Am Acad Dermatol. 2023 Mar;88(3):593-601. https://doi.org/10.1016/j.jaad.2022.11.010.
- Wang L, Zhang X, Meng X, Koskeridis F, Georgiou A, Yu L, Campbell H, Theodoratou E, Li X. Methodology in phenome-wide association studies: a systematic review. J Med Genet. 2021 Nov;58(11):720-728. https://doi.org/10.1136/jmedgenet-2021-107696.
- Vlachos GS, Kosmidis MH, Yannakoulia M, Dardiotis E, Hadjigeorgiou G, Tzoulaki I, Georgiou A, Sakka P, Anastasiou CA, Stefanis L, Scarmeas N. Dementia Incidence in the Elderly Population of Greece: Results From the HELIAD Study. Alzheimer Dis Assoc Disord. 2021 Jan-Mar 01;35(1):48-54. https://doi.org/10.1097/WAD.0000000000000407.
- Georgiou A, Ntritsos G, Papadimitriou N, Dimou N, Evangelou E. Cigarette Smoking, Coffee Consumption, Alcohol Intake, and Risk of Crohn’s Disease and Ulcerative Colitis: A Mendelian Randomization Study. Inflamm Bowel Dis. 2021 Jan 19;27(2):162-168. https://doi.org/10.1093/ibd/izaa152.
- Georgiou A, Demetriou CA, Christou YP, Heraclides A, Leonidou E, Loukaides P, Yiasoumi E, Pantziaris M, Kleopa KA, Papacostas SS, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Genetic and Environmental Factors Contributing to Parkinson’s Disease: A Case-Control Study in the Cypriot Population. Front Neurol. 2019 Oct 17;10:1047. https://doi.org/10.3389/fneur.2019.01047.
- Georgiou A, Demetriou CA, Heraclides A, Christou YP, Leonidou E, Loukaides P, Yiasoumi E, Panagiotou D, Manoli P, Thomson P, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Mitochondrial superclusters influence age of onset of Parkinson’s disease in a gender specific manner in the Cypriot population: A case-control study. PLoS One. 2017 Sep 6;12(9):e0183444. https://doi.org/10.1371/journal.pone.0183444.
Contact info:
Email: georgiou.andrea@ucy.ac.cy
Research Associate, Marie Skłodowska-Curie Fellow
Head of the Genetic Epidemiology Unit
Dr. Georgiou holds a B.Sc. in Molecular Biology & Genetics from Democritus University of Thrace, Greece, an M.Sc. in Human Molecular Genetics from Imperial College London, United Kingdom, and a Ph.D. in Medical Genetics from The Cyprus Institute of Neurology and Genetics, Cyprus
Her current research focuses on exploring genetic and molecular therapeutic targets for smoking addiction through drug repurposing Mendelian Randomization methodologies. Additionally, she is actively involved in other epidemiological research projects that investigate neurological and psychiatric diseases, as well as other complex traits and their underlying biological mechanisms.
Research Interests: Her research interests intersect genetics, epidemiology, drug repurposing and biostatistics, with a central focus on advancing our understanding of complex diseases, particularly within the realm of neuropsychiatric conditions, and the interplay of genetic and environmental determinants. Over the years, she has actively engaged in a diverse array of projects, spanning genetic epidemiology investigations involving mendelian randomization, polygenic risk scores, and genome- and protein-wide association analyses for complex diseases, including neurodegenerative and cardiovascular conditions. Her work also encompasses conducting observational studies that entail participant recruitment. She is deeply passionate about unraveling the genetic and environmental factors that contribute to complex health issues and leveraging this knowledge to shape public health interventions and inform medical practices.
For more information please visit:
Selected Publications:
- Georgiou A, Voskarides K, Zanos P, Chatzittofis A. Investigating the shared genetic basis and causal relationships between mucosa-associated lymphoid tissue inflammation and psychiatric disorders. Frontiers in Psychiatry, 2024, In Press. https://doi.org/10.3389/fpsyt.2024.1379922
- Georgiou A, Zagkos L, Markozannes G, Chalitsios CV, Asimakopoulos AG, Xu W, Wang L, Mesa-Eguiagaray I, Zhou X, Loizidou EM, Kretsavos N, Theodoratou E, Gill D, Burgess S, Evangelou E, Tsilidis KK, Tzoulaki I. Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies. J Am Heart Assoc. 2023 Oct 17;12(20):e029040. https://doi.org/10.1161/JAHA.122.029040.
- Georgiou A, Georgiopoulos G, Delialis D, Maneta E, Masci PG, Neophytou O, Tsiachris D, Evangelou E. The causal relationship between average alcohol consumption and risk of atrial fibrillation: a Mendelian randomization study, Circulation: Genomic and Precision Medicine, 2023 May 16:406–408. https://doi.org/10.1161/CIRCGEN.122.003766.
- Chalitsios CV, Georgiou A, Bouras E, Evangelou E, Gill D, Tsilidis KK, Tzoulaki I. Investigating modifiable pathways in psoriasis: A Mendelian randomization study. J Am Acad Dermatol. 2023 Mar;88(3):593-601. https://doi.org/10.1016/j.jaad.2022.11.010.
- Wang L, Zhang X, Meng X, Koskeridis F, Georgiou A, Yu L, Campbell H, Theodoratou E, Li X. Methodology in phenome-wide association studies: a systematic review. J Med Genet. 2021 Nov;58(11):720-728. https://doi.org/10.1136/jmedgenet-2021-107696.
- Vlachos GS, Kosmidis MH, Yannakoulia M, Dardiotis E, Hadjigeorgiou G, Tzoulaki I, Georgiou A, Sakka P, Anastasiou CA, Stefanis L, Scarmeas N. Dementia Incidence in the Elderly Population of Greece: Results From the HELIAD Study. Alzheimer Dis Assoc Disord. 2021 Jan-Mar 01;35(1):48-54. https://doi.org/10.1097/WAD.0000000000000407.
- Georgiou A, Ntritsos G, Papadimitriou N, Dimou N, Evangelou E. Cigarette Smoking, Coffee Consumption, Alcohol Intake, and Risk of Crohn’s Disease and Ulcerative Colitis: A Mendelian Randomization Study. Inflamm Bowel Dis. 2021 Jan 19;27(2):162-168. https://doi.org/10.1093/ibd/izaa152.
- Georgiou A, Demetriou CA, Christou YP, Heraclides A, Leonidou E, Loukaides P, Yiasoumi E, Pantziaris M, Kleopa KA, Papacostas SS, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Genetic and Environmental Factors Contributing to Parkinson’s Disease: A Case-Control Study in the Cypriot Population. Front Neurol. 2019 Oct 17;10:1047. https://doi.org/10.3389/fneur.2019.01047.
- Georgiou A, Demetriou CA, Heraclides A, Christou YP, Leonidou E, Loukaides P, Yiasoumi E, Panagiotou D, Manoli P, Thomson P, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Mitochondrial superclusters influence age of onset of Parkinson’s disease in a gender specific manner in the Cypriot population: A case-control study. PLoS One. 2017 Sep 6;12(9):e0183444. https://doi.org/10.1371/journal.pone.0183444.
Contact info:
Email: georgiou.andrea@ucy.ac.cy