Dr. Mary Haddad, BSc, MSc, Ph.D.
Postdoctoral, Marie Skłodowska-Curie Fellow
Mary will start working in the Zanos lab in June 2024. Dr. Haddad’s research interests revolve around exploring the complex interplay between molecular mechanisms, particularly focusing on the role of soluble epoxide hydrolase (sEH) and its inhibitors in conditions like depression, pain, inflammation, and neurodegenerative diseases. Her work delves into the connection between oxidative stress, depression, and the potential therapeutic implications of omega-3 polyunsaturated fatty acids in mitigating inflammation through the modulation of lipid mediators. Additionally, Dr. Haddad investigates the involvement of 20-HETE enzymes and receptors within the neurovascular unit, emphasizing their implications in cerebrovascular diseases, thus contributing significantly to our understanding of these complex physiological and pathological processes.
Dr. Haddad’s project in Dr. Zanos’s lab investigates the relationship between 20-HETE and EET metabolites in depression, exploring their link to inflammation and proposing novel therapeutic avenues. This involves characterizing CYP involvement in depressive symptoms, studying pharmacological interventions in rodents, and assessing the impact on neuronal function and pathology, aiming to translate these findings into potential clinical relevance for Major Depressive Disorder.
Selected Publications:
- Dannawi M, Riachi ME, Haddad AF, El Massry M, Haddad M, Moukarzel P et al. Influence of intermittent fasting on prediabetes-induced neuropathy: Insights on a novel mechanistic pathway. Metabol Open 2022; 14: 100175. https://doi.org/10.1016/j.metop.2022.100175.
- Haddad M, Eid S, Harb F, Massry MEL, Azar S, Sauleau EA et al. Activation of 20-HETE Synthase Triggers Oxidative Injury and Peripheral Nerve Damage in Type 2 Diabetic Mice. J Pain 2022; 23(8): 1371-1388. https://doi.org/10.1016/j.jpain.2022.02.011.
Contact info:
E-mail: mah92@mail.aub.edu
Dr. Elmar Mammadov, BSc, MSc, M.D.
Postdoctoral Fellow
Dr. Mammadov served as a postdoctoral fellow in the Zanos lab, collaborating with Dr. Zanos to establish most of the lab’s behavioral pharmacology techniques and ex vivo electrophysiology recording rigs.
His research focused on comprehending the precise neurobiological mechanisms behind the actions of ketamine and its metabolites. Specifically, he investigated their efficacy to reverse maladaptive behavioral responses and prevent relapse during prolonged drug abstinence, employing rodent models.
Currently, he is pursuing an additional Master’s program in Computer Science at the University of Pennsylvania, USA.
Selected Publications
- Michael, A.*, Onisiforou, A.*, Georgiou, P., Koumas, M., Powels, C., Mammadov, E., Georgiou A.N., Zanos, P. (2R,6R)-hydroxynorketamine prevents opioid abstinence-related negative affect and stress-induced reinstatement in mice. British Journal of Pharmacology, 2025, In Press. * Equal contribution. https://doi.org/10.1111/bph.70018.
- Michael A, Onisiforou A, Georgiou P, Koumas M, Mammadov E, Zanos P. (2R,6R)-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent mice. bioRxiv 2023: 2023.2012.2007.570550. https://doi.org/10.1101/2023.12.07.570550.
- Arikan T, Emek E, Bozkurt B, Mammadov E, Ceyhan O, Sahin T et al. Does Multiple Bile Duct Anastomosis in Living Donor Liver Transplantation Affect the Postoperative Biliary Complications? Transplant Proc 2019; 51(7): 2473-2477. https://doi.org/10.1016/j.transproceed.2019.01.160.
Dr. Derrick Phillips, BSc, MS, Ph.D.
Postdoctoral Fellow
Dr. Phillips served as the first postdoctoral fellow in the Zanos lab.
His research focused on understanding the effects of different drugs of abuse on sleep architecture during chronic administration, as well as following protracted abstinence.
Following his postdoctoral training in the Zanos lab, he secured a faculty position at the University of Idaho, USA, as an Assistant Professor of Circadian Biology.
Selected Publications
- Phillips DJ., Powels C., Zanos P. Protracted abstinence from chronic opioid administration induces REM-specific sleep disturbances in mice. In Preparation.
- Smith PC, Phillips DJ, Pocivavsek A, Byrd CA, Viechweg SS, Hampton B et al. Estradiol influences adenosinergic signaling and nonrapid eye movement sleep need in adult female rats. Sleep 2022; 45(3). https://doi.org/10.1093/sleep/zsab225.
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